Evaluation of oxidative stress
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HeadVincent RICHARD & Isabelle REMY-JOUET |
ContactIsabelle.Jouet@univ-rouen.fr |
Research TopicsRole of reactive oxygen/nitrogen species and oxygen-derived free radicals in health and diseases |
CompositionAdministrator: Vincent RICHARD, Director, Vincent.Richard@univ-rouen.fr Technical Contact Isabelle JOUET, IR Inserm, Isabelle.Jouet@univ-rouen.fr This platerforme is certified ISO 9001 |
Facilities3 electron paramagnetic spectroscopy (EPR) equipments31 chemiluminescence equipmentCollaboration with expert structures in EPR in France UMR CNRS 8516, 9036, 8601. |
ActivityDirect measurements of free radicals in human or animal blood and tissues , by EPR spectroscopy Direct measurements of plasma nitrates (reflecting NO production) in humans The facility received an ISO9001 quality certification in December 2012 |
Main ContributionsDevelopment of EPR specroscopy for the measurements of free radicals in human blood and tissue in correlation with cardiovascular studies (Bellien et al. Circulation, 2012 ; Montaigne et al. J Am Coll Cardiol. 2013) or in hearts or arteries from experimental animals (Favre et al. Am J Physiol, 2011 ; Merabet et al. J Mol Cell Cardiol. 2012) Use of chemiluminscence for the mesurements of NO , in relation with functional vascular studies, in human (Bellien et al. Hypertension 2012) or experimental animals (Fréguin et al. Transplantation 2011). Measurements of NO and free radicals in developing brain , in collaboration with Inserm ERI 28, Rouen (B Gonzalez) (El Ghazi et al. Neurobiol Dis 2012) |
Main Publications2014
2012
2013
2011
2007
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