Inserm Unit U1234 (PANTHER) |
Pathophysiology, Autoimmunity, Neuromuscular diseases and regenerative THERapies
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HeadPr Olivier Boyer, Director Pr Sophie Candon, Deputy Director Chantal Barou, Administrative Officer |
ContactResearch unit 1234 Inserm/University Faculty of Medicine and Pharmacy 22 Boulevard Gambetta 76183 Rouen Cedex Phone: +33 235 14 8535 chantal.barou@inserm.fr olivier.boyer@chu-rouen.fr |
Research Topics
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Composition
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Facilities
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ActivityThe research program of Inserm U1234 focuses on the immunopathology and the biotherapy of autoimmune diseases. Autoimmunity and its regulation are studied in physiological and pathological contexts, through murine models and clinical studies in the field of neuromuscular (myositis, multiple sclerosis) and skin (pemphigus) diseases. The program is divided into two thematic areas (A) A1. The first one centers on the immuno-regulation by ectonucleotides (ATP, NAD) or by neuropeptides (VIP, PACAP), and pathophysiological mechanisms of autoimmune diseases (myositis, multiple sclerosis, pemphigus). It is based on the development and analysis of murine models (transgenic, knock-out, viral gene transfer) and clinical studies. Focus is put on inflammatory mechanisms, oxidative stress, pathogenicity of auto-antibodies from patients and autoreactive B cell responses at a single-cell level. Immuno-assays are developed and translated to the clinic. A2. The second area has a therapeutic goal through the translation of cell and gene transfer strategies to clinical trials. This includes myoblast cell therapy, adipose-derived stem cell therapy, corneal tissue/cell transplantation and olfactory stem cells for neural regeneration. Inserm U1234 is a founding member of the FHU SURFACE and part of the LARC neuroscience network. |
Main Contributions
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Main Publications |