IRIB Normandy Rouen / Institute for Research and Innovation in Biomedicine

  Research and Services Laboratories

UMR6014 - COBRA - Organic and Bioorganic Chemistry, Reactivity, Analysis


 https://hal-normandie-univ.archives-ouvertes.fr/COBRA

Head: Pierre-Yves RENARD

Affiliations: Rouen Normandie University, CNRS, INSA

  Contact
CNRS UMR 6014
IRCOF
Rue Tesnière
76130 Mont Saint-Aignan

Phone: +33 235 52 2920
  cobra@insa-rouen.fr
  pannecoucke@insa-rouen.fr

  Keywords
ORGANIC CHEMISTRY, CHEMICAL BIOLOGY, SYNTHETIC METHODOLOGY, ANALYTICAL CHEMISTRY, SUSTAINABLE DEVELOPMENT

  Networks
Labex Synorg
  • Institut Carnot - Innovation Chimie Carnot (I2C)
  • Graduate school of research XL-Chem
  • Pathogènes, Environnement et Hôte : Une approche intégrée en santé respiratoire (RESPIRE, FHU)
  • European Network of Fourier-Transform Ion-Cyclotron-Resonance Mass Spectrometry Centers (EU-FTICR-MS)

  • GIS ChemBioFrance
  • GdR 2053 Synthèse en Flux (SynthFlux) [le directeur est Julien Legros du COBRA]
  • GdR 2037 Agents d’Imagerie Moléculaire (AIM)
  • GdR 2095 Chémobiologie
  • GdR 3625 MultiFonction des Peptides AntiMicrobiens (MuFoPAM)
  • Research network C-H Activation for Organic Synthesis (CHAOS)

  • Cosmetic Valley : Premier réseau mondial de la parfumerie-cosmétique
  • POLEPHARMA : Première filière pharmaceutique française
  • Consortium FINDMED : Fédération des 16 Instituts Carnot du secteur de la santé et du médicament
  • IAR : le pôle de la Bioéconomie

  •   Research Topics

      Composition

      Facilities

      Activity

    The COBRA unit is structured around six general scientific themes (analysis and modelling, bioorganic chemistry, synthesis of fluorinated molecules, organometallics, heterocycles & supramolecular and supported chemistry) and mainly works in the areas of organic, bioorganic, medicinal and analytic chemistryAmong applications, the preparation of compounds with biological interest, in collaboration with biology and pharmacy teams, takes a significant place.


    The goal of the bioorganic component is the preparation of biologically active compounds for various domains (cancer, cardiovascular, SNC, antiviral), the vectorization of active substances and the synthesis of probes  and bioconjugates  used in molecular imaging.


    The analysis and modelling component provides a support for the chemists to solve structural problems and develops its own research projects at the chemistry-biology interface. These projects are the structural characterization of peptide and protein domains by NMR and molecular modelling as well as the characterization of neuropeptide and GPCR interactions by NMR.


    The fact that the COBRA teams benefit from national and international recognition is shown by the numerous invitations, collaborations, and financed projects (ANR, Oséo, FEDER, Interreg, PAI-PHC). The unit has developed strong working relationships with academics and industrial leaders in pharmacy and biotechnology by the Technopôle Chimie-Biologie Santé, the “center for competiveness” Cosmetic valley, and the federal group, PharmaValley. Most of the teams of the unit have developed during this period, strong and durable partnerships with the industry of the pharmaceutical sector (SERVIER, ORIL, SANOFI-AVENTIS, JANSSEN/CILAG, VALDEPHARM, NUFARM, ISOCHEM, EXONIT Therapeutics, ROQUETTE Bros., AAA) and from foundational chemistry (TOTAL, ARKEMA).  ). A compound is in clinical development (a Servier Laboratoires collaboration) and IRIS Biotech has commercialized three compounds originating from research in bioorganic chemistry from the group.  The group also brings important support for the creation of start ups in biotechnology by welcoming the parties involved on its premises.  QUIDD (medical imagery) and POLYINTELL (Innovative polymers for diagnostics) have been hosted for several years in the group. Two start-ups have been created due to the group’s work: TFChem in 2007 (fluorinated sugar for the pharmaceutical industry) and CNS vector in 2011 (vectorization of active principals and radiotracers on the central nervous system).


      Main contributions

    1. Analysis and modelling: solution structure of neuropeptides determined by NMR and molecular modelling. Some of studied neuropeptides have been discovered by U982 Inserm unity (U-II, PACAP, 26RFa). Molecular interaction studies of these neuropeptides with its target (GPCR).  Structural studies of protein domains (v-Myb, Kin17) by NMR and molecular modelling.

    2. Bioorganic chemistry: competences in bioconjugation, screening and total synthesis in order to create flexible, user-friendly and biocompatible chemical tools and in order to explore the living complex mechanisms (fluorescence, proteomics, medical imaging, protein chips, immunodetection, innovative strategies for active biomolecule discovery, fight against neurotoxics).

    3. Synthesis of fluorinated biomolecules: development of new fluorinated molecule synthesis methodologies. Application to syntheses of nucleotides, amino acids, sugar mimetics and peptides for use in pharmaceutical and agrochemical domains.

    4. Heterocycles: development of new synthesis methodologies and heterocycle functionalization. Development in pharmacological domain (cancer, Alzheimer’s disease, pain and inflammation. Preparation of new fluorescent probes used as photosensitizers for the photodynamic diagnostic and therapy.

    5. Supramolecular and supported chemistry: development of new contrast agents for IRM quantification of enzymatic activities. Biomimetic catalysts for neurotoxic agent neutralizing.


     


      Latest publications

    2013

    2012


      Other Scientific Productions
    Brevets actifs

    ► Outils informatiques (logiciel, base de  données)


    Last update: -0001/11/30

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