IRIB Normandy Rouen

IRIB Normandy Rouen / Institute for Research and Innovation in Biomedicine

Administration

Research and Services Laboratories

Research Team EA 4108 - LITIS - Group Quantif Medical Imaging

Head: Pr Paquet

Affiliations: Rouen Normandie University, Ministry of Education and Research

Contact

QuantIF Laboratory - LITIS EA 4108
Faculty of Medicine and Pharmacy
22 Boulevard Gambetta
76183 Rouen Cedex, France
Phone: +33 232 0822 58

pierre.vera@rouen.fnclcc.fr

jean-nicolas.dacher@chu-rouen

Composition

15 teacher-researchers, engineers, technicians
3 graduate students

Facilities

Small animal imaging: micro-MRI 4.7T, microSPECT-CT and echography
Computer science laboratory
2 Medical imaging departments: Radiology Dept of Rouen University Hospital and Nuclear Medicine Dept of the Henri Becquerel Cancer Centre : MRI (1/2 dedicated to clinical research), CT-scan, SPECT-CT, PET-CT, echography
Radiotherapy Dept: 3 linear accelerators, intensity modulated radiation therapy (IMRT)

Activity

The aims of Quant.I.F (Quantification in Functional Imaging) group integrated to the 4108 LITIS laboratory (Director: Stéphane Canu) are the quantification and characterisation of healthy and pathological tissues based on functional imaging modalities in humans and small animals (MRI, PET-CT, CT and SPECT-CT). We focused our work on moving organs and, more particularly, on thoracic organs. Our specific segmentation methods have been developed on the basis of on phantom studies (physical and numerical using Monte-Carlo simulations techniques). We also performed animal and human studies. The Quant.I.F group collaborates with different labs of Rouen University [Inserm U644, IRCOF (UMR CNRS 6014), LMRS (UMR CNRS 6085)] and also plays an important role in the north-west Cancéropôle (imaging and radiotherapy). The group has close collaborations with international teams (Florida, Bruxelles and New York) and industrial companies (Siemens, GE medical Systems).

Main contributions

Adaptation of "belief functions" to the segmentation of thoracic tumors and renal volume (included in the tool "MR Urography" of ImageJ - NIH)
Optimization of volumes measurements in PET-CT for the definition of "Gross Tumor Volume (GTV)" in external beam radiation
Interest of functional imaging during radiotherapy to evaluate patients prognostic
Development and imaging with in vivo confoncal fluorescence microscopy of the lung
Fusion imaging multimodalities in PET-CT (metabolism, hypoxia, cell tumor proliferation)
Optimizing the gated imaging (heart gated-SPECT, lung gated PET)

Latest publications

2012

DÃ©sir C, Petitjean C, Heutte L, SalaÃ¼n M and Thiberville L. Classification of endomicroscopic images of the lung based on random subwindows and extra-trees. IEEE Trans Biomed Eng 2012, 59: 2677-83.
22907955
SalaÃ¼n M, Roussel F, Bourg-Heckly G, Vever-Bizet C, Dominique S, Genevois A, Jounieaux V, Zalcman G, Bergot E, Jean-Michel V and Thiberville L. In vivo probe-based confocal laser endomicroscopy in amiodarone-related pneumonia. Eur Respir J 2012
23018901

2011

Hapdey S, Buvat I, Carson JM, Carrasquillo JA, Whatley M and Bacharach SL. Searching for alternatives to full kinetic analysis in 18F-FDG PET: an extension of the simplified kinetic analysis method. J Nucl Med 2011, 52: 634-41.
21421718
Vera P, Bohn P, Edet-Sanson A, Salles A, Hapdey S, Gardin I, MÃ©nard JF, Modzelewski R, Thiberville L and Dubray B. Simultaneous positron emission tomography (PET) assessment of metabolism with 18F-fluoro-2-deoxy-d-glucose (FDG), proliferation with 18F-fluoro-thymidine (FLT), and hypoxia with 18fluoro-misonidazole (F-miso) before and dur. Radiother Oncol 2011, 98: 109-16.
21056487

2010

SalaÃ¼n M, Roussel F, Hauss PA, Lachkar S and Thiberville L. In vivo imaging of pulmonary alveolar proteinosis using confocal endomicroscopy. Eur Respir J 2010, 36: 451-3.
20675784
Tylski P, Stute S, Grotus N, Doyeux K, Hapdey S, Gardin I, Vanderlinden B and Buvat I. Comparative assessment of methods for estimating tumor volume and standardized uptake value in (18)F-FDG PET. J Nucl Med 2010, 51: 268-76.
20080896

Last update: -0001/11/30

Nous contacter :

IRIB Normandy Rouen
22 Boulevard Gambetta
76183 ROUEN Cedex
France

Direction :
contact@irib-normandy.fr

Secretariat :
secretariat@irib-normandy.fr

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