Composition

• 28 researchers, engineers, technicians
• 10 PhD Students, 5 master students

  Facilities

• Small laboratory animals Magnetic Resonance Imaging (MRI)

• Experimental and clinical cardiac imaging (echocardiography, tissue Doppler, MRI)

• Clinical vascular imaging (echo-tracking, tonometry)

• Experimental vascular imaging (arteriograph, myograph)

• Electron paramagnetic resonance

• Chemiluminescence

  Activity

• Research performed in Inserm U1096 Unit, concerns the evaluation of the mechanisms and the treatment of cardiovascular diseases, and especially vascular protection and improvement of cardiac contractile function. This research is transversal, and performed both in experimental model and in human.
• Regarding vascular research, our work mostly concerns the protection of vascular endothelial cells in the context of cardiovascular risk factors or cardiovascular diseases (hypertension, diabetes, myocardial infarction, heart failure etc. ). We also investigate new biotherapy approaches for stimulation of angiogenesis and vasculogenesis.
• Regarding cardiac research, our work mostly concerns the improvement of noninvasive detection of cardiac contractile dysfunction, the search for new treatments of heart failure, the study of the links between oxidative stress and heart failure, as well as the clinical evaluation of percutaneous aortic valve replacement.

  Main contributions

• Role of cytochrome P450-derived hyperpolarizing factors (EDHF) in endothelium-dependent vasodilatation in human, and consequences of its pharmacological restoration in cardio-metabolic diseases
• Endothelial protective effects and reduction of heart failure by tyrosine phosphatase 1B inhibition
• Beneficial effects of pharmacological heart rate reduction in heart failure
• Discovery and clinical evaluation of percutaneous aortic valve replacement
• Treatment of heart failure by localized slow delivery of angiogenic growth factors

  Latest publications

2012

• Gilard M, Eltchaninoff H, Iung B, Donzeau-Gouge P, Chevreul K, Fajadet J, Leprince P, Leguerrier A, Lievre M, Prat A, Teiger E, Lefevre T, Himbert D, Tchetche D, Carrié D, Albat B, Cribier A, Rioufol G, Sudre A, Blanchard D, Collet F, Dos Santos P, Men. Registry of transcatheter aortic-valve implantation in high-risk patients. N Engl J Med 2012, 366: 1705-15.
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2011

• Banquet S, Gomez E, Nicol L, Edwards-Lévy F, Henry JP, Cao R, Schapman D, Dautreaux B, Lallemand F, Bauer F, Cao Y, Thuillez C, Mulder P, Richard V and Brakenhielm E. Arteriogenic therapy by intramyocardial sustained delivery of a novel growth factor combination prevents chronic heart failure. Circulation 2011, 124: 1059-69.
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