Networks

• Groupe d’étude thérapeutique des affections inflammatoires du tube Digestif (GETAID)
• Groupe français de neuro-gastroentérologie (GFNG)
• Fédération Française Anorexie Boulimie (FFAB)
• French Network for Nutrition and Cancer Research (NACRe network)
• Registre des Maladies inflammatoires chroniques de l’intestin (EPIMAD)
• Société francophone nutrition clinique et métabolisme (SFNCM)
• Société nationale française de gastro-entérologie (SNFGE)
• VALORIAL - Pôle de compétitivité agroalimentaire


• European Symposium on Substance Use among Students network (ESSUS network)
• Joint Programming Initiative a Healthy Diet for a Healthy Life (JPI HDHL)

  Research Topics

• Nutrients and intestinal metabolism
• Immunonutrition and innovative nutrition formulas
• Physiopathology of eating-disorders and anorexia nervosa
• Irritable Bowel Syndrome: physiopathology, environmental factors
• Innovative therapeutics (immunonutrition, neurostimulation) and biotech industries

  Composition

• 30 teacher-researchers, researchers, engineers, technicians
• 18 graduate students, 3 undergraduate students

  Facilities

• Intestinal models: cell lines, human intestinal explants, experimental colitis
• Mass spectrometric analysis and in vivo isotopic studies, proteomics
• Rodent and human DEXA
• Digestive function investigation platform (motility, sensitivity, endoscopy)
• Neurostimulation and neuronavigation systems

  Activity

The works of our group are mainly dedicated to the study of eating disorders, irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD). These pathologies share common features of intestinal inflammation and dysregulation of the gut-brain axis and offer great opportunities for innovative therapeutic strategies (immunonutrition, neurostimulation). Our investigations explore the underlying mechanisms of these diseases from the molecular level to clinical trials. This broad range of research from the bench to the bedside is the result of our research strategy that brings together basic and clinical sciences, in a tight collaboration between laboratory scientists and health professionals. Our dynamic research team has an active research strategy which also drives the translation of research from the laboratory to patenting and creation of biotech companies entrepreneurship.

  Main contributions

• Study and nutritional modulation of gut protein metabolism under inflammatory conditions: IBD, IBS and eating-disorders
• Study of dysregulation of gut-brain axis during eating disorders and IBS: pathophysiology and innovative therapeutic approaches
• Development of innovative formula for intestinal inflammation-targeted nutrients or drugs and of central or peripheric neurostimulation techniques
• Epidemiological studies (eating-disorders, IBD and IBS)

  Latest publications

2018

• Nobis S, Goichon A, Achamrah N, , Guérin C, Azhar S, Chan P, Morin A, Bôle-Feysot C, do Rego JC, Vaudry D, , Déchelotte P, , Belmonte L, and Coëffier M,. Alterations of proteome, mitochondrial dynamic and autophagy in the hypothalamus during activity-based anorexia. Sci Rep 2018, 8: 7233.
  29740148

2016

• Belmonte L, Achamrah N, Nobis S, Guérin C, Riou G, Bôle-Feysot C, Boyer O, Richard V, Rego JC, Déchelotte P, Goichon A and Coëffier M. A role for intestinal TLR4-driven inflammatory response during activity-based anorexia. Sci Rep 2016, 6: 35813.
  27779218
• Breton J, Tennoune N, Lucas N, Francois M, Legrand R, Jacquemot J, Goichon A, Guérin C, Peltier J, Pestel-Caron M, Chan P, Vaudry D, do Rego JC, Liénard F, Pénicaud L, Fioramonti X, Ebenezer IS, Hökfelt T, Déchelotte P and Fetissov SO. Gut Commensal E. coli Proteins Activate Host Satiety Pathways following Nutrient-Induced Bacterial Growth. Cell Metab 2016, 23: 324-34.
  26621107
• Charpentier C, Chan R, Salameh E, Mbodji K, Ueno A, Coëffier M, Guérin C, Ghosh S, Savoye G, and Marion-Letellier R. Dietary n-3 PUFA May Attenuate Experimental Colitis. Mediators Inflamm 2018, 2018: 8430614.
  29670469
• Melchior C, Bril L, Leroi AM, Gourcerol G, and Ducrotté P. Are characteristics of abdominal pain helpful to identify patients with visceral hypersensitivity in irritable bowel syndrome? Results of a prospective study. Neurogastroenterol Motil 2018
  29345401
• Sacleux SC, Sarter H, Fumery M, Charpentier C, Guillon-Dellac N, Coevoet H, Pariente B, Peyrin-Biroulet L, Gower-Rousseau C, and Savoye G; EPIMAD Group. Post-operative complications in elderly onset inflammatory bowel disease: a population-based study. Aliment Pharmacol Ther 2018
  29737553
• Tavolacci MP, Delay J, Grigioni S, Déchelotte P, and Ladner J. Changes and specificities in health behaviors among healthcare students over an 8-year period. PLoS One 2018, 13: e0194188.
  29566003

2017

• Ghouzali I, Lemaitre C, Bahlouli W, Azhar S, Bôle-Feysot C, Meleine M, Ducrotté P, Déchelotte P and Coëffier M. Targeting immunoproteasome and glutamine supplementation prevent intestinal hyperpermeability. Biochim Biophys Acta 2017, 1861: 3278-3288.
  27544233
• Langlois LD, Le Long E, Meleine M, Antor M, Atmani K, Dechelotte P, Leroi AM, and Gourcerol G. Acute sacral nerve stimulation reduces visceral mechanosensitivity in a cross-organ sensitization model. Neurogastroenterol Motil 2017, 29:  10.1111/nmo.
  27997083
• Marion-Letellier R, Bohn P, Modzelewski R, Vera P, Aziz M, Guérin C, Savoye G and Savoye-Collet C. SPECT-computed tomography in rats with TNBS-induced colitis: A first step toward functional imaging. World J Gastroenterol 2017, 23: 216-223.
  28127195

  Other Scientific Productions

• WO2015082633 - INFLUENCE BACTERIENNE SUR LA REGULATION DE L'APPETIT PAR MIMETISME ENTRE LA PROTEINE CLP B ET L'ALPHA MSH
• WO2018185080 - PROTÉINES DÉRIVÉES DE CLPB ET LEURS UTILISATIONS
• WO2016059455 - COMPOSITIONS PHARMACEUTIQUES ET ALIMENTAIRE POUR INDUIRE UN SENTIMENT DE SATIÉTÉ ET PROLONGER UN SENTIMENT DE CHEZ DES SUJETS EN AYANT BESOIN
• WO2018185082 - EXTRAIT DE PROTEINE DE BRASSICACEAE ET UTILISATIONS ASSOCIEES

► Outils informatiques (logiciel, base de  données)

• EDILS “Eating disorders inventory longitudinal study” with biocollection (blood, feces) - (CNIL no. 1787487; CODECOH N° DC-2014 -2189) [cohortes avec biocollection]
• OTFI “Observatoire des patients souffrant de troubles fonctionnels digestifs”. N°DRCI : 2019/120/OB ID RCB : 2019-A01423-54 [cohortes avec biocollection]
• ELSE “ Logitudinal study for students’ health” (Projet Ta santé en un Clic) [cohorte observationnelle]

► Développement d'instruments

• MiniStim: Miniaturized implantable stimulation device (Patent PCT/EP2016/070567)