Research Team EA 4358 Rouen Normandie University, Ministry of Education and Research |
Glycobiology and Plant Extracellular Matrix |
Glyco-MEV |
HeadPr Patrice LEROUGE - Pr Azeddine DRIOUICH Secretary: Gérald BELLANGER |
ContactEA 4358 Faculté des Sciences et Techniques 76821 Mont-Saint-Aignan Cedex Phone: +33 235 14 6394 patrice.lerouge@univ-rouen.fr azeddine.driouich@univ-rouen.fr |
Research Topics
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Composition
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Facilities
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ActivityResearch activities in the laboratory «Glycobiologie et Matrice Extracellulaire Végétale » aim at elucidating the function and biosynthesis of glycoproteins and polysaccharides in higher plants and microalgae. We focus mainly, through reverse genetic approaches, on the function of polysaccharides in relation with plant development and morphogenesis. Another aspect of our research activity deals with defence mechanisms occurring specifically in root border cells with the ultimate goal of identifying identify novel molecules able to stimulate the plant immunity against pathogens. Finally, we also investigate the protein glycosylation processing in higher plants and microalgae by studying N-glycan pathways, glycosyltransferase activities and their Golgi localisation. Since plants and microalgae synthesize N-glycans that are immunogenic in humans, the aim of this topic is to engineer the endogenous processing to produce in glycoproteins carrying human-compatible glycosylation patterns. The laboratory has also gained an international recognition in the cell imaging of carbohydrate epitopes using both confocal and cryo-electron microscopies. |
Main Contributions
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Main Publications2015
2014
2013 |