Composition

Administrator: Vincent RICHARD, Director, Vincent.Richard@univ-rouen.fr

Technical Contact Isabelle JOUET, IR Inserm, Isabelle.Jouet@univ-rouen.fr

This platerforme is certified ISO 9001

  Facilities

3 electron paramagnetic spectroscopy (EPR) equipments

3 

 1 chemiluminescence equipment

Collaboration with expert structures in EPR in France UMR CNRS 8516, 9036, 8601.

  Activity

Direct measurements of free radicals in human or animal blood and tissues , by EPR spectroscopy

Direct measurements of plasma nitrates (reflecting NO production) in humans

The facility received an ISO9001 quality certification in December 2012

  Main contributions

Development of EPR specroscopy for the measurements of free radicals in human blood and tissue in correlation with cardiovascular studies (Bellien et al. Circulation, 2012 ; Montaigne et al. J Am Coll Cardiol. 2013) or in hearts or arteries from experimental animals (Favre et al. Am J Physiol, 2011 ; Merabet et al. J Mol Cell Cardiol. 2012)

Use of chemiluminscence for the mesurements of NO , in relation with functional vascular studies, in human (Bellien et al. Hypertension 2012)  or experimental animals (Fréguin et al. Transplantation 2011).

Measurements of NO and free radicals in developing brain , in collaboration with Inserm ERI 28, Rouen (B Gonzalez) (El Ghazi et al. Neurobiol Dis 2012)

  Latest publications

2014

• Coquerel D, Neviere R, Delile E, Mulder P, Marechal X, Montaigne D, Renet S, Remy-Jouet I, Gomez E, Henry JP, do Rego JC, Richard V and Tamion F. Gene Deletion of Protein Tyrosine Phosphatase 1B Protects Against Sepsis-Induced Cardiovascular Dysfunction and Mortality. Arterioscler Thromb Vasc Biol 2014
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2012

• Bellien J, Iacob M, Remy-Jouet I, Lucas D, Monteil C, Gutierrez L, Vendeville C, Dreano Y, Mercier A, Thuillez C and Joannides R. Epoxyeicosatrienoic acids contribute with altered nitric oxide and endothelin-1 pathways to conduit artery endothelial dysfunction in essential hypertension. Circulation 2012, 125: 1266-75.
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2013

• Bellien J, Fréguin-Bouilland C, Joannidès R, Hanoy M, Rémy-Jouet I, Monteil C, Iacob M, Martin L, Renet S, Vendeville C, Godin M, Thuillez C and Le Roy F. High-efficiency on-line haemodiafiltration improves conduit artery endothelial function compared with high-flux haemodialysis in end-stage renal disease patients. Nephrol Dial Transplant 2013
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• Montaigne D, Marechal X, Lefebvre P, Modine T, Fayad G, Dehondt H, Hurt C, Coisne A, Koussa M, Remy-Jouet I, Zerimech F, Boulanger E, Lacroix D, Staels B and Neviere R. Mitochondrial dysfunction as an arrhythmogenic substrate: a translational proof-of-concept study in patients with metabolic syndrome in whom post-operative atrial fibrillation develops. J Am Coll Cardiol 2013, 62: 1466-73.
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2011

• Favre J, Gao J, Zhang AD, Remy-Jouet I, Ouvrard-Pascaud A, Dautreaux B, Escoubet B, Thuillez C, Jaisser F and Richard V. Coronary endothelial dysfunction after cardiomyocyte-specific mineralocorticoid receptor overexpression. Am J Physiol Heart Circ Physiol 2011, 300: H2035-43.
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• Fréguin-Bouilland C, Godin M, Bellien J, Richard V, Remy-Jouet I, Dautreaux B, Henry JP, Compagnon P, Thuillez C, Plissonnier D and Joannidès R. Protective effect of mycophenolate mofetil on endothelial function in an aortic allograft model. Transplantation 2011, 91: 35-41.
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2007

• Favre J, Musette P, Douin-Echinard V, Laude K, Henry JP, Arnal JF, Thuillez C and Richard V. Toll-like receptors 2-deficient mice are protected against postischemic coronary endothelial dysfunction. Arterioscler Thromb Vasc Biol 2007, 27: 1064-71.
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• El Ghazi F, Desfeux A, Brasse-Lagnel C, Roux C, Lesueur C, Mazur D, Remy-Jouet I, Richard V, Jégou S, Laudenbach V, Marret S, Bekri S, Prevot V and Gonzalez BJ. NO-dependent protective effect of VEGF against excitotoxicity on layer VI of the developing cerebral cortex. Neurobiol Dis 2012, 45: 871-86.
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