• Home 
  • General Presentation 
    • What's irib?
    • Composition
  • Research Laboratories 
    • CIC-CRB 1404 - Clinical Research Centre - Biological Resources Center  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Inserm Unit U1096 - Endothelium, Valvulopathy & Heart Failure (EnVI)  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Inserm Unit U1073 - Digestive Tract Environment and Nutrition   
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Inserm Unit U1234 - Pathophysiology, Autoimmunity and Immunotherapy  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
      • FOCIS Center of Excellence
    • Inserm Unit U1239 - Neuronal and Neuroendocrine Differenciation and Communication  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Inserm Unit U1245 - Genomic and Personalized Medicine in Cancer and Neurological disorders  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Research Team EA 2656 - Research group on antimicrobial agents and microorganisms  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Research Team EA 3830  - Ventilary Handicap Research Group  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Research Team EA 4108 - Data Processing in Biology & Health (LITIS)  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Research Team EA 4108 - Quantif Medical Imaging Group (LITIS)  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Research Team EA 4308  - Gametogenesis and gamete quality  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Research Team EA 4312 - Laboratory of Microbiology Signals and Microenvironment  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Research Team EA 4358 - Glycobiology and Plant Extracellular Matrix  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Research Team EA 7510 ESCAPE - Foodborne protozoan diseases  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Research Unit UMR6014 - Organic and Bioorganic Chemistry, Reactivity, Analysis  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Research Unit UMR6270 - Polymers, Biopolymers, Surfaces, Biofilm Resistance, Cell-Surface Interactions group  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
  • Facilities 
    • Behavioral Analysis Facility  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Cell Imaging platform of Normandy  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Evaluation of oxidative stress  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Flow Cytometry and Cell Analysis Facility  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Genomic Analysis Facility  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Nuclear Magnetic Resonance Spectroscopy Facility  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Proteomic Facility  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Small Animal Magnetic Resonance Imaging Facility  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
  • Publications
  • Letters
  • Meetings  
    • 2022/06/10 - JNRB2022 - Rouen  
    • 2019/11/19 - JNRB2019 - Pôle de Formation et de Recherche en Santé de Caen  
    • 2018/09/20 - JNRB2018 - Batiment Stewart UFR Santé Rouen  
    • 2017/11/14 - JNRB2017 - Caen  
    • 2016/09/16 - JNRB2016 - Rouen UFR Médecine Pharmacie  
    • 2015/06/05 - 4e journée IRIB - Rouen UFR Médecine Pharmacie  
    • 2014/06/20 - 3e journée IRIB - Manoir Henri IV de Caugé (Agglomération d'Evreux)  
    • 2013/06/21 - 2e journée IRIB - Maison de l'Université Rouen  
    • >> Symposium  

Research Laboratories

Inserm Unit U1073



Digestive Tract Environment and Nutrition

ADEN


Head


Pr Pierre Dechelotte


Contact


Research Unit U1073
22, Boulevard Gambetta
CS 76183
76183 ROUEN CEDEX
FRANCE
Phone: +33 235 1482 40
pierre.dechelotte@chu-rouen.fr
sylvie.martins@univ-rouen.fr


Research Topics


  • Nutrients and intestinal metabolism
  • Immunonutrition and innovative nutrition formulas
  • Physiopathology of eating-disorders and anorexia nervosa
  • Irritable Bowel Syndrome: physiopathology, environmental factors
  • Innovative therapeutics (immunonutrition, neurostimulation) and biotech industries



Composition


  • 30 teacher-researchers, researchers, engineers, technicians
  • 18 graduate students, 3 undergraduate students



Facilities


  • Intestinal models: cell lines, human intestinal explants, experimental colitis
  • Mass spectrometric analysis and in vivo isotopic studies, proteomics
  • Rodent and human DEXA
  • Digestive function investigation platform (motility, sensitivity, endoscopy)
  • Neurostimulation and neuronavigation systems



Activity


The works of our group are mainly dedicated to the study of eating disorders, irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD). These pathologies share common features of intestinal inflammation and dysregulation of the gut-brain axis and offer great opportunities for innovative therapeutic strategies (immunonutrition, neurostimulation). Our investigations explore the underlying mechanisms of these diseases from the molecular level to clinical trials. This broad range of research from the bench to the bedside is the result of our research strategy that brings together basic and clinical sciences, in a tight collaboration between laboratory scientists and health professionals. Our dynamic research team has an active research strategy which also drives the translation of research from the laboratory to patenting and creation of biotech companies entrepreneurship.


Main Contributions


  • Study and nutritional modulation of gut protein metabolism under inflammatory conditions: IBD, IBS and eating-disorders
  • Study of dysregulation of gut-brain axis during eating disorders and IBS: pathophysiology and innovative therapeutic approaches
  • Development of innovative formula for intestinal inflammation-targeted nutrients or drugs and of central or peripheric neurostimulation techniques
  • Epidemiological studies (eating-disorders, IBD and IBS)



Main Publications


2018

  • Nobis S, Goichon A, Achamrah N, , Guérin C, Azhar S, Chan P, Morin A, Bôle-Feysot C, do Rego JC, Vaudry D, , Déchelotte P, , Belmonte L, and Coëffier M,. Alterations of proteome, mitochondrial dynamic and autophagy in the hypothalamus during activity-based anorexia. Sci Rep 2018, 8: 7233.
    29740148

2016

  • Belmonte L, Achamrah N, Nobis S, Guérin C, Riou G, Bôle-Feysot C, Boyer O, Richard V, Rego JC, Déchelotte P, Goichon A and Coëffier M. A role for intestinal TLR4-driven inflammatory response during activity-based anorexia. Sci Rep 2016, 6: 35813.
    27779218
  • Breton J, Tennoune N, Lucas N, Francois M, Legrand R, Jacquemot J, Goichon A, Guérin C, Peltier J, Pestel-Caron M, Chan P, Vaudry D, do Rego JC, Liénard F, Pénicaud L, Fioramonti X, Ebenezer IS, Hökfelt T, Déchelotte P and Fetissov SO. Gut Commensal E. coli Proteins Activate Host Satiety Pathways following Nutrient-Induced Bacterial Growth. Cell Metab 2016, 23: 324-34.
    26621107
  • Charpentier C, Chan R, Salameh E, Mbodji K, Ueno A, Coëffier M, Guérin C, Ghosh S, Savoye G, and Marion-Letellier R. Dietary n-3 PUFA May Attenuate Experimental Colitis. Mediators Inflamm 2018, 2018: 8430614.
    29670469
  • Melchior C, Bril L, Leroi AM, Gourcerol G, and Ducrotté P. Are characteristics of abdominal pain helpful to identify patients with visceral hypersensitivity in irritable bowel syndrome? Results of a prospective study. Neurogastroenterol Motil 2018
    29345401
  • Sacleux SC, Sarter H, Fumery M, Charpentier C, Guillon-Dellac N, Coevoet H, Pariente B, Peyrin-Biroulet L, Gower-Rousseau C, and Savoye G; EPIMAD Group. Post-operative complications in elderly onset inflammatory bowel disease: a population-based study. Aliment Pharmacol Ther 2018
    29737553
  • Tavolacci MP, Delay J, Grigioni S, Déchelotte P, and Ladner J. Changes and specificities in health behaviors among healthcare students over an 8-year period. PLoS One 2018, 13: e0194188.
    29566003

2017

  • Ghouzali I, Lemaitre C, Bahlouli W, Azhar S, Bôle-Feysot C, Meleine M, Ducrotté P, Déchelotte P and Coëffier M. Targeting immunoproteasome and glutamine supplementation prevent intestinal hyperpermeability. Biochim Biophys Acta 2017, 1861: 3278-3288.
    27544233
  • Langlois LD, Le Long E, Meleine M, Antor M, Atmani K, Dechelotte P, Leroi AM, and Gourcerol G. Acute sacral nerve stimulation reduces visceral mechanosensitivity in a cross-organ sensitization model. Neurogastroenterol Motil 2017, 29:  10.1111/nmo.
    27997083
  • Marion-Letellier R, Bohn P, Modzelewski R, Vera P, Aziz M, Guérin C, Savoye G and Savoye-Collet C. SPECT-computed tomography in rats with TNBS-induced colitis: A first step toward functional imaging. World J Gastroenterol 2017, 23: 216-223.
    28127195

Lettre de l'IRIB - juin 2022

La Lettre de l’IRIB du mois de juin 2022 (n°86) est en ligne.

Pour consulter les archives, merci de cliquer ici

Séminaire HeRacLeS

Le DR. Emmanuel G. REYNAUD présentera aujourd'hui le séminaire "Après les organoïdes ?" de 16h à 17h dans l'amphi du CURIB.

20 ans du CIC


PROGRAMMES

Lettre de l'IRIB - avril 2022

La Lettre de l’IRIB du mois d'avril 2022 (n°85) est en ligne.

Pour consulter les archives, merci de cliquer ici.

LATEST NEWS    ARCHIVE



Events


Connexion


Newsletter


CONTACT US
logo
IRIB Normandy Rouen
22 Boulevard Gambetta
76183 ROUEN Cedex
France

Direction
contact@irib-normandy.fr

Secretariat
secretariat@irib-normandy.fr

logo logo
Design by Alexis Lebon © IRIB Normandy Rouen, 2012 - All rights reserved.