Research Laboratories

Inserm Unit U1073
Digestive Tract Environment and Nutrition

ADEN


Head


Pr Pierre Dechelotte


Contact


Research Unit U1073
22, Boulevard Gambetta
CS 76183
76183 ROUEN CEDEX
FRANCE
Phone: +33 235 1482 40
pierre.dechelotte@chu-rouen.fr
sylvie.martins@univ-rouen.fr


Research Topics


  • Nutrients and intestinal metabolism
  • Immunonutrition and innovative nutrition formulas
  • Physiopathology of eating-disorders and anorexia nervosa
  • Irritable Bowel Syndrome: physiopathology, environmental factors
  • Innovative therapeutics (immunonutrition, neurostimulation) and biotech industries

Composition


  • 30 teacher-researchers, researchers, engineers, technicians
  • 18 graduate students, 3 undergraduate students

Facilities


  • Intestinal models: cell lines, human intestinal explants, experimental colitis
  • Mass spectrometric analysis and in vivo isotopic studies, proteomics
  • Rodent and human DEXA
  • Digestive function investigation platform (motility, sensitivity, endoscopy)
  • Neurostimulation and neuronavigation systems

Activity


The works of our group are mainly dedicated to the study of eating disorders, irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD). These pathologies share common features of intestinal inflammation and dysregulation of the gut-brain axis and offer great opportunities for innovative therapeutic strategies (immunonutrition, neurostimulation). Our investigations explore the underlying mechanisms of these diseases from the molecular level to clinical trials. This broad range of research from the bench to the bedside is the result of our research strategy that brings together basic and clinical sciences, in a tight collaboration between laboratory scientists and health professionals. Our dynamic research team has an active research strategy which also drives the translation of research from the laboratory to patenting and creation of biotech companies entrepreneurship.


Main Contributions


  • Study and nutritional modulation of gut protein metabolism under inflammatory conditions: IBD, IBS and eating-disorders
  • Study of dysregulation of gut-brain axis during eating disorders and IBS: pathophysiology and innovative therapeutic approaches
  • Development of innovative formula for intestinal inflammation-targeted nutrients or drugs and of central or peripheric neurostimulation techniques
  • Epidemiological studies (eating-disorders, IBD and IBS)

Main Publications


2018

  • Nobis S, Goichon A, Achamrah N, , Guérin C, Azhar S, Chan P, Morin A, Bôle-Feysot C, do Rego JC, Vaudry D, , Déchelotte P, , Belmonte L, and Coëffier M,. Alterations of proteome, mitochondrial dynamic and autophagy in the hypothalamus during activity-based anorexia. Sci Rep 2018, 8: 7233.
    29740148

2016

  • Belmonte L, Achamrah N, Nobis S, Guérin C, Riou G, Bôle-Feysot C, Boyer O, Richard V, Rego JC, Déchelotte P, Goichon A and Coëffier M. A role for intestinal TLR4-driven inflammatory response during activity-based anorexia. Sci Rep 2016, 6: 35813.
    27779218
  • Breton J, Tennoune N, Lucas N, Francois M, Legrand R, Jacquemot J, Goichon A, Guérin C, Peltier J, Pestel-Caron M, Chan P, Vaudry D, do Rego JC, Liénard F, Pénicaud L, Fioramonti X, Ebenezer IS, Hökfelt T, Déchelotte P and Fetissov SO. Gut Commensal E. coli Proteins Activate Host Satiety Pathways following Nutrient-Induced Bacterial Growth. Cell Metab 2016, 23: 324-34.
    26621107
  • Charpentier C, Chan R, Salameh E, Mbodji K, Ueno A, Coëffier M, Guérin C, Ghosh S, Savoye G, and Marion-Letellier R. Dietary n-3 PUFA May Attenuate Experimental Colitis. Mediators Inflamm 2018, 2018: 8430614.
    29670469
  • Melchior C, Bril L, Leroi AM, Gourcerol G, and Ducrotté P. Are characteristics of abdominal pain helpful to identify patients with visceral hypersensitivity in irritable bowel syndrome? Results of a prospective study. Neurogastroenterol Motil 2018
    29345401
  • Sacleux SC, Sarter H, Fumery M, Charpentier C, Guillon-Dellac N, Coevoet H, Pariente B, Peyrin-Biroulet L, Gower-Rousseau C, and Savoye G; EPIMAD Group. Post-operative complications in elderly onset inflammatory bowel disease: a population-based study. Aliment Pharmacol Ther 2018
    29737553
  • Tavolacci MP, Delay J, Grigioni S, Déchelotte P, and Ladner J. Changes and specificities in health behaviors among healthcare students over an 8-year period. PLoS One 2018, 13: e0194188.
    29566003

2017

  • Ghouzali I, Lemaitre C, Bahlouli W, Azhar S, Bôle-Feysot C, Meleine M, Ducrotté P, Déchelotte P and Coëffier M. Targeting immunoproteasome and glutamine supplementation prevent intestinal hyperpermeability. Biochim Biophys Acta 2017, 1861: 3278-3288.
    27544233
  • Langlois LD, Le Long E, Meleine M, Antor M, Atmani K, Dechelotte P, Leroi AM, and Gourcerol G. Acute sacral nerve stimulation reduces visceral mechanosensitivity in a cross-organ sensitization model. Neurogastroenterol Motil 2017, 29:  10.1111/nmo.
    27997083
  • Marion-Letellier R, Bohn P, Modzelewski R, Vera P, Aziz M, Guérin C, Savoye G and Savoye-Collet C. SPECT-computed tomography in rats with TNBS-induced colitis: A first step toward functional imaging. World J Gastroenterol 2017, 23: 216-223.
    28127195