Inserm Unit U1234 |
Pathophysiology, Autoimmunity and Immunotherapy
|
FOCIS Excellence Center PAn'THER
|
HeadPr Olivier Boyer, Director Pr Sophie Candon, Deputy Director Chantal Barou, Administrative Officer |
ContactResearch unit 1234 Inserm/University Faculty of Health 22 Boulevard Gambetta 76183 Rouen Cedex Phone: +33 235 14 8535 chantal.barou@inserm.fr olivier.boyer@chu-rouen.fr To request an internship (L3, M1 or M2 students), contact us at demande.stage.u1234@univ-rouen.fr |
Research Topics
|
Composition
|
Facilities
|
ActivityThe research program of Inserm U1234 focuses on the cellular and molecular pathophysiological mechanisms involved in the onset and progression of myositis and autoimmune bullous cutaneous diseases. In these two clinical contexts and some related diseases such as rheumatoid arthritis, we aim at delineating the pathogenic roles of autoreactive B cells and autoantibodies (aAbs). This is done through both (i) experimental studies based on animal immunization or autoantibody/cell transfer, as well as spontaneous autoimmune animal models or new models under development and, (ii) translational studies with in-depth characterization of human autoreactive B cell responses at the bulk and single cell level and structural/functional features of aAbs isolated from patients. On the therapeutic side, we design new therapeutic tools for immunointervention in cancer and autoimmunity including cell/gene therapy (lentiviral vectors and AAV, CAR/CAAR-T cells, nanobodies). These immunotherapies are evaluated in experimental models of myositis, bullous diseases and cancer. Thanks to our close collaboration with clinical departments and ATMP facility of Rouen University Hospital, we conduct or participate in several immunotherapy clinical trials. The work of Inserm U1234 in the field of myositis, autoimmune bullous diseases and T-cell immunotherapy is the core research project of the PAn’THER Center of Excellence (Director O. Boyer, deputy director C. Abad) of the US-based Federation of Clinical Immunology Societies. https://irib.univ-rouen.fr/focis.php |
Main Contributions
|
Main Publications2021
2020
2019
2018
2017
|