Research Laboratories

CIC-CRB 1404
Clinical Research Centre - Biological Resources Center


Head


Pr. Anne-Marie Leroi - Dr. Marie-Pierre Tavolacci - Dr. Eglantine Ferrand Devouge - Dr. Muriel Quillard-Muraine


Contact


Centre d'Investigation Clinique CHU de Rouen
1 rue de Germont
76031 Rouen cedex
Phone: +33 232 88 8862
secretariat.CIC@chu-rouen.fr
anne-marie.leroi@chu-rouen.fr  

https://www.chu-rouen.fr/service/centre-dinvestigation-clinique/


Research Topics


TYPES OF RESEARCH
  • Biomedical drug research: 56 % (mainly phase II and III clinical trials)
  • Physiological studies: 22 %
  • Genetic studies: 5 %
  • Medical devices: 8 %
  • Cohort studies: 9 %

FIELDS OF RESEARCH
  • Cardiovascular, Nutrition, Digestive System Disease: 11 %
  • Neurosciences, Neurology: 26 %
  • Genetics, Cancer, Immunology: 21 %
  • Diagnostic and therapeutic innovation: 42 %

Composition


·         45 researchers, engineers, technicians

·         1 Quality referent, 1 Biostatistician, 1 Lawyer

 




Facilities


 
  • Coordinator Site (CIC-CRB 1404):
    • CIC 1404:
      • Site Authorization for Healthy Volunteer Trials
      • File of 1500 healthy volunteers
      • Methodological support
      • 3 clinical trials dedicated beds with 3 scopes
      • 2 ECG
      • 1 defibrillator
      • Main access to functionnal imaging and exploration
    • Biological Resources Centre
      • Impedancemeter
      • 7 Ultra Low Temperature Freezer (-80°C)
      • 4 Ultra Low Temperature Freezer (-20°C)
      • Laboratory centrifuges
      • Main access to Tumour banks (Federation of Pathology CRLCC-CHU)
  • Endocrinology and Diabetology Site (U 1239):
    • Ultra Low Temperature Freezer (-80°C).
    • Ultra Low Temperature Freezer (-20°C)
    • Laboratory centrifuges
  • Neurology Site (U 1245 & U 1073):
    • Main access to diseases biomarkers
    • Functionnal imaging and exploration (MRI 3T).
    • PET imaging
    • CSF biomarkers
    • Neurosurgical team with expertise in deep brain neurostimulation
    • Site Authorization for Healthy Volunteer Trials
    • 2 polysomnography and 2 multiparameter recorders
  • Nutrition Site (U 1073):
    • Body composition through DEXA or bio-impedancemeter
    • Bone Densitometry
    • Calorimeter
    • Mass spectrometric analysis and in vivo isotopic studies
  • Pediatrics Site (U 1239):
    • Ultra Low Temperature Freezer (-20°C)
    • Laboratory centrifuges
  • Pharmacology Site (U 1096):
    • Clinical vascular imaging (echo-tracking, tonometry)
    • Site Authorization for Healthy Volunteer Trials
  • Physiology Site (U 1073):
    • Digestive function investigation platform (manometry, barostat, electrophysiological studies, breath tests, gastric emptying, impedancemetry, sphincter planimetry..)
    • Digestive Neurostimulation
    • Magnetic transcranial stimulation
    • Site Authorization for Healthy Volunteer Trials
  • Pneumology Site (EA 4108):
    • In vivo confocal endomicroscopy (Cellvizio®)
  • Rheumatology Site (U 1234):
    • Ultrasonography
    • Bone mineral densitometry
    • Ultra Low Temperature Freezer (-80°C).
    • 6 Ultra Low Temperature Freezer (-20°C)
    • Laboratory centrifuges.
    • Access to radiology department
  • Urology Site:
    • Surgical robot
    • Koelis system (prostate targeted biopsies)
    • Hexvix Fluorescence (bladder cancer)
    • Chemotherapy Unit with access to immunotherapy and antiangiogenic therapies

Activity


The Clinical Investigation Centre (Inserm-CIC 1404) and Biological Resources Centre is an ambulatory care and hospitalization Centre dedicated to clinical trials. It includes a coordinating site and 9 clinical sites (see table). The CIC-CRB 1404 was labeled in 2002, recently renewed in 2016. Research taking place in the Centre covers all medical and surgical specialties.
All types of studies are concerned: phases I to IV clinical trials, evaluation of medical devices,
epidemiological, physiological and diagnostic studies. Technical resources also benefit from other several associated units facilities present within the Departments of epidemiology, Physiology, Pneumology, Endocrinology, Neurology, Nutrition, Pharmacology, Rheumatology, Urology and Pediatrics of the University hospital. The mission of the CIC-CRB 1404 is to provide facilities and resources (staff, methodology, equipment….) to researchers performing clinical studies. The CIC-CRB 1404 especially promotes translational research based on close interactions between scientists and physicians of the medical campus. Our objective is to produce new scientific and medical knowledge while ensuring compliance with ethical and legal requirements.
The CIC-CRB 1404 also participates in the training and teaching of clinical research: Master “Methods in Clinical Pharmacology and Training in Therapeutic Trials” and D.I.U. Investigator in Biomedical Research.


Main Contributions


From 2010 to 2015, 255 research protocols:
  • Institutional (65%);
  • private pharmaceutical companies (35%).

Main Publications


2018

  • Patout M, Sesé L, Gille T, Coiffard B, Korzeniewski S, Lhuillier E, Pradel A, Tardif C, Chambellan A, , Straus C, , Matecki S, Perez T, , Thiberville L, and Didier A. Does training respiratory physicians in clinical respiratory physiology and interpretation of pulmonary function tests improve core knowledge. Thorax 2018, 73: 78-81.
    28258249
  • Pulido M, Roubaud G, Cazeau AL, Mahammedi H, Vedrine L, Joly F, Mourey L, Pfister C, Goberna A, Lortal B, Bellera C, Pourquier P and Houédé N. Safety and efficacy of temsirolimus as second line treatment for patients with recurrent bladder cancer. BMC Cancer 2018, 18: 194.
    29454321
  • Wils J, Djerada Z, Roca F, Duflot T, Iacob M, Remy-Jouet I, Joannides R and Bellien J. Alteration in the availability of epoxyeicosatrienoic acids contributes with NO to the development of endothelial dysfunction in conduit arteries during aging. Atherosclerosis 2018, 275: 239-245.
    29980050

2017

  • Achamrah N, Coëffier M, Rimbert A, Charles J, Folope V, Petit A, Déchelotte P and Grigioni S. Micronutrient Status in 153 Patients with Anorexia Nervosa. Nutrients 2017, 9:  E225.
    28257095
  • Boyer O, Bridoux V, Giverne C, Bisson A, Koning E, Leroi AM, Chambon P, Déhayes J, Le Corre S, Jacquot S, Bastit D, Martinet J, Houivet E, Tuech JJ, Benichou J and Michot F; and the Study Group of Myoblast Therapy for Faecal Incontinence. Autologous Myoblasts for the Treatment of Fecal Incontinence: Results of a Phase 2 Randomized Placebo-controlled Study (MIAS). Ann Surg 2017
    28426476
  • Brito-Zerón P, Acar-Denizli N, Zeher M, Rasmussen A, Seror R, Theander E, Li X, Baldini C, Gottenberg JE, Danda D, Quartuccio L, Priori R, Hernandez-Molina G, Kruize AA, Valim V, Kvarnstrom M, Sene D, Gerli R, Praprotnik S, Isenberg D, Solans R, Rischmueller M, Kwok SK, Nordmark G, Suzuki Y, Giacomelli R, Devauchelle-Pensec V, Bombardieri M, Hofauer B, Bootsma H, Brun JG, Fraile G, Carsons SE, Gheita TA, Morel J, Vollenveider C, Atzeni F, Retamozo S, Horvath IF, Sivils K, Mandl T, Sandhya P, De Vita S, Sanchez-Guerrero J, van der Heijden E, Trevisani VFM, Wahren-Herlenius M, Mariette X and Ramos-Casals M,; EULAR-SS Task Force Big Data Consortium. Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sjögren Project Consortium. Ann Rheum Dis 2017, 76: 1042-1050.
    27899373
  • Marie I, Gehanno JF, Bubenheim M, Duval-Modeste AB, Joly P, Dominique S, Bravard P, Noël D, Cailleux AF, Benichou J, Levesque H and Goullé JP. Systemic sclerosis and exposure to heavy metals: A case control study of 100 patients and 300 controls. Autoimmun Rev 2017, 16: 223-230.
    28137480
  • Mas JL, Derumeaux G, Guillon B, Massardier E, Hosseini H, Mechtouff L, Arquizan C, Béjot Y, Vuillier F, Detante O, Guidoux C, Canaple S, Vaduva C, Dequatre-Ponchelle N, Sibon I, Garnier P, Ferrier A, Timsit S, Robinet-Borgomano E, Sablot D, Lacour JC, Zuber M, Favrole P, Pinel JF, Apoil M, Reiner P, Lefebvre C, Guérin P, Piot C, Rossi R, Dubois-Randé JL, Eicher JC, Meneveau N, Lusson JR, Bertrand B, Schleich JM, Godart F, Thambo JB, Leborgne L, Michel P, Pierard L, Turc G, Barthelet M, Charles-Nelson A, Weimar C, Moulin T, Juliard JM and Chatellier G; CLOSE Investigators. Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke. N Engl J Med 2017, 377: 1011-1021.
    28902593
  • Neal B, Perkovic V, Mahaffey KW, de Zeeuw D, Fulcher G, Erondu N, Shaw W, Law G, Desai M and Matthews DR; CANVAS Program Collaborative Group. Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes. N Engl J Med 2017, 377: 644-657.
    28605608
  • Saguintaah M, Cabon Y, Gauthier R, Duboibaudry C, Couderc L, Le Bourgeois M, Reix P, Chiron R, Arrada IT, Molinari N and Matecki S. A simplified, semi-quantitative structural lung disease computed tomography outcome during quiet breathing in infants with cystic fibrosis. J Cyst Fibros 2017, 16: 151-157.
    27888005