Research Laboratories

CIC-CRB 1404
Clinical Research Centre - Biological Resources Center


Head


Pr. Anne-Marie Leroi - Dr. Marie-Pierre Tavolacci - Dr. Eglantine Ferrand Devouge - Dr. Muriel Quillard-Muraine


Contact


Centre d'Investigation Clinique CHU de Rouen
Hôpital Charles-Nicolle
37, boulevard Gambetta - 76000 ROUEN
https://www.chu-rouen.fr/service/centre-dinvestigation-clinique/


Research Topics


TYPES OF RESEARCH
  • Biomedical drug research: 56 % (mainly phase II and III clinical trials)
  • Physiological studies: 22 %
  • Genetic studies: 5 %
  • Medical devices: 8 %
  • Cohort studies: 9 %

FIELDS OF RESEARCH
  • Cardiovascular, Nutrition, Digestive System Disease: 11 %
  • Neurosciences, Neurology: 26 %
  • Genetics, Cancer, Immunology: 21 %
  • Diagnostic and therapeutic innovation: 42 %

Composition


  • 45 researchers, engineers, technicians
  • 1 Quality referent, 1 Epidemiologist, 1 Lawyer

Facilities


  • Coordinator Site (CIC-CRB 1404) :
    • CIC 1404:
      • Site Authorization for Healthy Volunteer Trials
      • File of 1800 healthy volunteers
      • Methodological support
      • clinical trials dedicated beds with scopes
      • ECG
      • Defibrillator
      • Main access to functionnal imaging and exploration
    • Biological Resources Centre
      • Impedancemeter
      • Ultra Low Temperature Freezer (-150° and -80°C)
      • Low Temperature Freezer (-20°C and -4°C)
      • Laboratory centrifuges
      • Main access to Tumour banks (Federation of Pathology CRLCC-CHU)
  • Endocrinology and Diabetology Site (U 1239):
    • Ultra Low Temperature Freezer (-80°C)
    • Low Temperature Freezer (-20°C)
    • Laboratory centrifuges
  • Neurology Site (U 1245 & U 1073):
    • Main access to diseases biomarkers
    • Functionnal imaging and exploration (MRI 3T).
    • PET imaging
    • CSF biomarkers
    • Neurosurgical team with expertise in deep brain neurostimulation
    • Site Authorization for Healthy Volunteer Trials
    • 2 polysomnography and 2 multiparameter recorders
  • Nutrition Site (U 1073) :
    • Body composition through DEXA or bio-impedancemeter
    • Bone Densitometry
    • Calorimeter
    • Mass spectrometric analysis and in vivo isotopic studies
  • Pediatrics Site (U 1239):
    • Ultra Low Temperature Freezer (-20°C)
    • Laboratory centrifuges
  • Pharmacology Site (U 1096):
    • Clinical vascular imaging (echo-tracking, ultrasound, flattening tonometer)
    • Bio-impedancemeter
    • Site Authorization for Healthy Volunteer Trials
  • Physiology Site (U 1073):
    • Digestive function investigation platform (manometry, barostat, electrophysiological studies, breath tests, gastric emptying, impedancemetry, sphincter planimetry..)
    • Digestive Neurostimulation
    • Magnetic transcranial stimulation
    • Site Authorization for Healthy Volunteer Trials
  • Pneumology Site (EA 4108):
    • In vivo confocal endomicroscopy (Cellvizio®)
  • Rheumatology Site (U 1234):
    • Ultrasonography
    • Bone mineral densitometry
    • Ultra Low Temperature Freezer (-80°C)
    • 6 Ultra Low Temperature Freezer (-20°C)
    • Laboratory centrifuges
    • Access to radiology department
  • Urology Site:
    • Surgical robot
    • Koelis system (prostate targeted biopsies)
    • Hexvix Fluorescence (bladder cancer)
    • Chemotherapy Unit with access to immunotherapy and antiangiogenic therapies

Activity


The Clinical Investigation Centre (Inserm-CIC 1404) and Biological Resources Centre is an ambulatory care and hospitalization Centre dedicated to clinical trials. It includes a coordinating site and 9 clinical sites (see table). The CIC-CRB 1404 was labeled as an “Inserm-CIC” in 2002, recently renewed in 2016. Research taking place in the Centre covers all medical and surgical specialties. All types of studies are concerned: phases I to IV clinical trials, evaluation of medical devices, epidemiological, physiological and diagnostic studies. Technical resources also benefit from other several associated units facilities present within the Departments of epidemiology, Physiology, Pneumology, Endocrinology, Neurology, Nutrition, Pharmacology, Rheumatology, Urology and Pediatrics of the University hospital. The mission of the CIC-CRB 1404 is to provide facilities and resources (staff, methodology, equipment….) to researchers performing clinical studies. The CIC-CRB 1404 especially promotes translational research based on close interactions between scientists and physicians of the medical campus. Our objective is to produce new scientific and medical knowledge while ensuring compliance with ethical and legal requirements. Since January 2021, CIC-CRB 1404 is also certified to ISO 9001 standard for its biological resources management and its investigation activities. The CIC-CRB 1404 also participates in the training and teaching of clinical research: Master “Methods in Clinical Pharmacology and Training in Therapeutic Trials” and D.I.U. Investigator in Biomedical Research.


Main Contributions


  • Institutional (65%);
  • private pharmaceutical companies (35%).

Main Publications


2021

  • Bendavid I, Lobo DN, Barazzoni R, Cederholm T, Coëffier M, de van der Schueren M, Fontaine E, Hiesmayr M, Laviano A, Pichard C and Singer P. The centenary of the Harris-Benedict equations: How to assess energy requirements best? Recommendations from the ESPEN expert group. Clin Nutr 2021, 40(3): 690-701.
    33279311
  • Combe B, Rincheval N, Berenbaum F, Boumier P, Cantagrel A, Dieude P, Dougados M, Fautrel B, Flipo RM, Goupille P, Mariette X, Saraux A, Schaeverbeke T, Sibilia J, Vittecoq O and Daurès JP. Current favourable 10-year outcome of patients with early rheumatoid arthritis: data from the ESPOIR cohort. Rheumatology (Oxford) 2021, keab398
    33961011
  • Ken-Dror G, Cotlarciuc I, Martinelli I, Grandone E, Hiltunen S, Lindgren E, Margaglione M, Duchez VLC, Triquenot AB, Zedde M, Mancuso M, Ruigrok YM, Marjot T, Worrall B, Majersik JJ, Metso TM, Putaala J, Haapaniemi E, Zuurbier SM, Brouwer MC, Passamonti SM, Abbattista M, Bucciarelli P, Mitchell BD, Kittner SJ, Lemmens R, Jern C, Pappalardo E, Costa P, Colombi M, de Sousa DA, Rodrigues S, Canhão P, Tkach A, Santacroce R, Favuzzi G, Arauz A, Colaizzo D, Spengos K, Hodge A, Ditta R, Pezzini A, Debette S, Coutinho JM, Thijs V, Jood K, Pare G, Tatlisumak T, Ferro JM, Sharma P and . Genome-wide association study identifies first locus associated with susceptibility to cerebral venous thrombosis. Ann Neurol 2021
    34459509
  • Pfister C, Gravis G, Fléchon A, Soulié M, Guy L, Laguerre B, Mottet N, Joly F, Allory Y, Harter V, Culine S and . Randomized Phase III Trial of Dose-dense Methotrexate, Vinblastine, Doxorubicin, and Cisplatin, or Gemcitabine and Cisplatin as Perioperative Chemotherapy for Patients with Muscle-invasive Bladder Cancer. Analysis of the GETUG/AFU V05 VESPER Trial Secondary Endpoints: Chemotherapy Toxicity and Pathological Responses. Eur Urol 2021, 79(2): 214-221.
    32868138

2020

  • Ducrotte P, Coffin B, Bonaz B, Fontaine S, Bruley Des Varannes S, Zerbib F, Caiazzo R, Grimaud JC, Mion F, Hadjadj S, Valensi PE, Vuitton L, Charpentier G, Ropert A, Altwegg R, Pouderoux P, Dorval E, Dapoigny M, Duboc H, Benhamou PY, Schmidt A, Donnadieu N, Gourcerol G, Guerci B and . Gastric Electrical Stimulation Reduces Refractory Vomiting in a Randomized Crossover Trial. Gastroenterology 2020, 158(3): 506-514.e2.
    31647902
  • Guisier F, Dubos-Arvis C, Viñas F, Doubre H, Ricordel C, Ropert S, Janicot H, Bernardi M, Fournel P, Lamy R, Pérol M, Dauba J, Gonzales G, Falchero L, Decroisette C, Assouline P, Chouaid C and Bylicki O. Efficacy and Safety of Anti-PD-1 Immunotherapy in Patients With Advanced NSCLC With BRAF, HER2, or MET Mutations or RET Translocation: GFPC 01-2018. J Thorac Oncol 2020, 15(4): 628-636.
    31945494
  • Wils J, Duparc C, Cailleux AF, Lopez AG, Guiheneuf C, Boutelet I, Boyer HG, Dubessy C, Cherifi S, Cauliez B, Gobet F, Defortescu G, Ménard JF, Louiset E and Lefebvre H. The neuropeptide substance P regulates aldosterone secretion in human adrenals. Nat Commun 2020, 11(1): 2673.
    32471973

2019

  • Bénard M, Bellisle F, Kesse-Guyot E, Julia C, Andreeva VA, Etilé F, Reach G, Dechelotte P, Tavolacci MP, Hercberg S and Péneau S. Impulsivity is associated with food intake, snacking, and eating disorders in a general population. Am J Clin Nutr 2019, 109(1): 117-126.
    30596882

2018

  • Roca F, Iacob M, Remy-Jouet I, Bellien J and Joannides R. Evidence for a Role of Vascular Endothelium in the Control of Arterial Wall Viscosity in Humans. Hypertension 2018, 71(1): 143-150.
    29158357