• Home 
  • General Presentation 
    • What's irib?
    • Composition
  • Research Laboratories 
    • CIC-CRB 1404 - Clinical Research Centre - Biological Resources Center  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Inserm Unit U1096 - Endothelium, Valvulopathy & Heart Failure (EnVI)  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Inserm Unit U1073 - Digestive Tract Environment and Nutrition   
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Inserm Unit U1234 - Pathophysiology, Autoimmunity and Immunotherapy  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
      • FOCIS Center of Excellence
    • Inserm Unit U1239 - Neuronal and Neuroendocrine Differenciation and Communication  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Inserm Unit U1245 - Genomic and Personalized Medicine in Cancer and Neurological disorders  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Research Team EA 2656 - Research group on antimicrobial agents and microorganisms  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Research Team EA 3830  - Ventilary Handicap Research Group  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Research Team EA 4108 - Data Processing in Biology & Health (LITIS)  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Research Team EA 4108 - Quantif Medical Imaging Group (LITIS)  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Research Team EA 4308  - Gametogenesis and gamete quality  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Research Team EA 4312 - Laboratory of Microbiology Signals and Microenvironment  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Research Team EA 4358 - Glycobiology and Plant Extracellular Matrix  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Research Team EA 7510 ESCAPE - Foodborne protozoan diseases  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Research Unit UMR6014 - Organic and Bioorganic Chemistry, Reactivity, Analysis  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Research Unit UMR6270 - Polymers, Biopolymers, Surfaces, Biofilm Resistance, Cell-Surface Interactions group  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
  • Facilities 
    • Behavioral Analysis Facility  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Cell Imaging platform of Normandy  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Evaluation of oxidative stress  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Flow Cytometry and Cell Analysis Facility  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Genomic Analysis Facility  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Nuclear Magnetic Resonance Spectroscopy Facility  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Proteomic Facility  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
    • Small Animal Magnetic Resonance Imaging Facility  
      • Research Topics
      • Composition
      • Facilities
      • Activity
      • Main Contributions
      • Main Publications
  • Publications
  • Letters
  • Meetings  
    • 2022/06/10 - JNRB2022 - Rouen  
    • 2019/11/19 - JNRB2019 - Pôle de Formation et de Recherche en Santé de Caen  
    • 2018/09/20 - JNRB2018 - Batiment Stewart UFR Santé Rouen  
    • 2017/11/14 - JNRB2017 - Caen  
    • 2016/09/16 - JNRB2016 - Rouen UFR Médecine Pharmacie  
    • 2015/06/05 - 4e journée IRIB - Rouen UFR Médecine Pharmacie  
    • 2014/06/20 - 3e journée IRIB - Manoir Henri IV de Caugé (Agglomération d'Evreux)  
    • 2013/06/21 - 2e journée IRIB - Maison de l'Université Rouen  
    • >> Symposium  

Research Laboratories

CIC-CRB 1404



Clinical Research Centre - Biological Resources Center


Head


Pr. Anne-Marie Leroi - Dr. Marie-Pierre Tavolacci - Dr. Eglantine Ferrand Devouge - Dr. Muriel Quillard-Muraine


Contact


Centre d'Investigation Clinique CHU de Rouen
Hôpital Charles-Nicolle
37, boulevard Gambetta - 76000 ROUEN



https://www.chu-rouen.fr/service/centre-dinvestigation-clinique/


Research Topics


TYPES OF RESEARCH
  • Biomedical drug research: 56 % (mainly phase II and III clinical trials)
  • Physiological studies: 22 %
  • Genetic studies: 5 %
  • Medical devices: 8 %
  • Cohort studies: 9 %

FIELDS OF RESEARCH
  • Cardiovascular, Nutrition, Digestive System Disease: 11 %
  • Neurosciences, Neurology: 26 %
  • Genetics, Cancer, Immunology: 21 %
  • Diagnostic and therapeutic innovation: 42 %



Composition


  • 45 researchers, engineers, technicians
  • 1 Quality referent, 1 Epidemiologist, 1 Lawyer





Facilities


  • Coordinator Site (CIC-CRB 1404) :
    • CIC 1404:
      • Site Authorization for Healthy Volunteer Trials
      • File of 1800 healthy volunteers
      • Methodological support
      • clinical trials dedicated beds with scopes
      • ECG
      • Defibrillator
      • Main access to functionnal imaging and exploration
    • Biological Resources Centre
      • Impedancemeter
      • Ultra Low Temperature Freezer (-150° and -80°C)
      • Low Temperature Freezer (-20°C and -4°C)
      • Laboratory centrifuges
      • Main access to Tumour banks (Federation of Pathology CRLCC-CHU)
  • Endocrinology and Diabetology Site (U 1239):
    • Ultra Low Temperature Freezer (-80°C)
    • Low Temperature Freezer (-20°C)
    • Laboratory centrifuges
  • Neurology Site (U 1245 & U 1073):
    • Main access to diseases biomarkers
    • Functionnal imaging and exploration (MRI 3T).
    • PET imaging
    • CSF biomarkers
    • Neurosurgical team with expertise in deep brain neurostimulation
    • Site Authorization for Healthy Volunteer Trials
    • 2 polysomnography and 2 multiparameter recorders
  • Nutrition Site (U 1073) :
    • Body composition through DEXA or bio-impedancemeter
    • Bone Densitometry
    • Calorimeter
    • Mass spectrometric analysis and in vivo isotopic studies
  • Pediatrics Site (U 1239):
    • Ultra Low Temperature Freezer (-20°C)
    • Laboratory centrifuges
  • Pharmacology Site (U 1096):
    • Clinical vascular imaging (echo-tracking, ultrasound, flattening tonometer)
    • Bio-impedancemeter
    • Site Authorization for Healthy Volunteer Trials
  • Physiology Site (U 1073):
    • Digestive function investigation platform (manometry, barostat, electrophysiological studies, breath tests, gastric emptying, impedancemetry, sphincter planimetry..)
    • Digestive Neurostimulation
    • Magnetic transcranial stimulation
    • Site Authorization for Healthy Volunteer Trials
  • Pneumology Site (EA 4108):
    • In vivo confocal endomicroscopy (Cellvizio®)
  • Rheumatology Site (U 1234):
    • Ultrasonography
    • Bone mineral densitometry
    • Ultra Low Temperature Freezer (-80°C)
    • 6 Ultra Low Temperature Freezer (-20°C)
    • Laboratory centrifuges
    • Access to radiology department
  • Urology Site:
    • Surgical robot
    • Koelis system (prostate targeted biopsies)
    • Hexvix Fluorescence (bladder cancer)
    • Chemotherapy Unit with access to immunotherapy and antiangiogenic therapies



Activity


The Clinical Investigation Centre (Inserm-CIC 1404) and Biological Resources Centre is an ambulatory care and hospitalization Centre dedicated to clinical trials. It includes a coordinating site and 9 clinical sites (see table). The CIC-CRB 1404 was labeled as an “Inserm-CIC” in 2002, recently renewed in 2016. Research taking place in the Centre covers all medical and surgical specialties. All types of studies are concerned: phases I to IV clinical trials, evaluation of medical devices, epidemiological, physiological and diagnostic studies. Technical resources also benefit from other several associated units facilities present within the Departments of epidemiology, Physiology, Pneumology, Endocrinology, Neurology, Nutrition, Pharmacology, Rheumatology, Urology and Pediatrics of the University hospital. The mission of the CIC-CRB 1404 is to provide facilities and resources (staff, methodology, equipment….) to researchers performing clinical studies. The CIC-CRB 1404 especially promotes translational research based on close interactions between scientists and physicians of the medical campus. Our objective is to produce new scientific and medical knowledge while ensuring compliance with ethical and legal requirements. Since January 2021, CIC-CRB 1404 is also certified to ISO 9001 standard for its biological resources management and its investigation activities. The CIC-CRB 1404 also participates in the training and teaching of clinical research: Master “Methods in Clinical Pharmacology and Training in Therapeutic Trials” and D.I.U. Investigator in Biomedical Research.


Main Contributions


  • Institutional (65%);
  • private pharmaceutical companies (35%).



Main Publications


2021

  • Bendavid I, Lobo DN, Barazzoni R, Cederholm T, Coëffier M, de van der Schueren M, Fontaine E, Hiesmayr M, Laviano A, Pichard C and Singer P. The centenary of the Harris-Benedict equations: How to assess energy requirements best? Recommendations from the ESPEN expert group. Clin Nutr 2021, 40(3): 690-701.
    33279311
  • Combe B, Rincheval N, Berenbaum F, Boumier P, Cantagrel A, Dieude P, Dougados M, Fautrel B, Flipo RM, Goupille P, Mariette X, Saraux A, Schaeverbeke T, Sibilia J, Vittecoq O and Daurès JP. Current favourable 10-year outcome of patients with early rheumatoid arthritis: data from the ESPOIR cohort. Rheumatology (Oxford) 2021, keab398
    33961011
  • Ken-Dror G, Cotlarciuc I, Martinelli I, Grandone E, Hiltunen S, Lindgren E, Margaglione M, Duchez VLC, Triquenot AB, Zedde M, Mancuso M, Ruigrok YM, Marjot T, Worrall B, Majersik JJ, Metso TM, Putaala J, Haapaniemi E, Zuurbier SM, Brouwer MC, Passamonti SM, Abbattista M, Bucciarelli P, Mitchell BD, Kittner SJ, Lemmens R, Jern C, Pappalardo E, Costa P, Colombi M, de Sousa DA, Rodrigues S, Canhão P, Tkach A, Santacroce R, Favuzzi G, Arauz A, Colaizzo D, Spengos K, Hodge A, Ditta R, Pezzini A, Debette S, Coutinho JM, Thijs V, Jood K, Pare G, Tatlisumak T, Ferro JM, Sharma P and . Genome-wide association study identifies first locus associated with susceptibility to cerebral venous thrombosis. Ann Neurol 2021
    34459509
  • Pfister C, Gravis G, Fléchon A, Soulié M, Guy L, Laguerre B, Mottet N, Joly F, Allory Y, Harter V, Culine S and . Randomized Phase III Trial of Dose-dense Methotrexate, Vinblastine, Doxorubicin, and Cisplatin, or Gemcitabine and Cisplatin as Perioperative Chemotherapy for Patients with Muscle-invasive Bladder Cancer. Analysis of the GETUG/AFU V05 VESPER Trial Secondary Endpoints: Chemotherapy Toxicity and Pathological Responses. Eur Urol 2021, 79(2): 214-221.
    32868138

2020

  • Ducrotte P, Coffin B, Bonaz B, Fontaine S, Bruley Des Varannes S, Zerbib F, Caiazzo R, Grimaud JC, Mion F, Hadjadj S, Valensi PE, Vuitton L, Charpentier G, Ropert A, Altwegg R, Pouderoux P, Dorval E, Dapoigny M, Duboc H, Benhamou PY, Schmidt A, Donnadieu N, Gourcerol G, Guerci B and . Gastric Electrical Stimulation Reduces Refractory Vomiting in a Randomized Crossover Trial. Gastroenterology 2020, 158(3): 506-514.e2.
    31647902
  • Guisier F, Dubos-Arvis C, Viñas F, Doubre H, Ricordel C, Ropert S, Janicot H, Bernardi M, Fournel P, Lamy R, Pérol M, Dauba J, Gonzales G, Falchero L, Decroisette C, Assouline P, Chouaid C and Bylicki O. Efficacy and Safety of Anti-PD-1 Immunotherapy in Patients With Advanced NSCLC With BRAF, HER2, or MET Mutations or RET Translocation: GFPC 01-2018. J Thorac Oncol 2020, 15(4): 628-636.
    31945494
  • Wils J, Duparc C, Cailleux AF, Lopez AG, Guiheneuf C, Boutelet I, Boyer HG, Dubessy C, Cherifi S, Cauliez B, Gobet F, Defortescu G, Ménard JF, Louiset E and Lefebvre H. The neuropeptide substance P regulates aldosterone secretion in human adrenals. Nat Commun 2020, 11(1): 2673.
    32471973

2019

  • Bénard M, Bellisle F, Kesse-Guyot E, Julia C, Andreeva VA, Etilé F, Reach G, Dechelotte P, Tavolacci MP, Hercberg S and Péneau S. Impulsivity is associated with food intake, snacking, and eating disorders in a general population. Am J Clin Nutr 2019, 109(1): 117-126.
    30596882

2018

  • Roca F, Iacob M, Remy-Jouet I, Bellien J and Joannides R. Evidence for a Role of Vascular Endothelium in the Control of Arterial Wall Viscosity in Humans. Hypertension 2018, 71(1): 143-150.
    29158357

Lettre de l'IRIB - juin 2022

La Lettre de l’IRIB du mois de juin 2022 (n°86) est en ligne.

Pour consulter les archives, merci de cliquer ici

Séminaire HeRacLeS

Le DR. Emmanuel G. REYNAUD présentera aujourd'hui le séminaire "Après les organoïdes ?" de 16h à 17h dans l'amphi du CURIB.

20 ans du CIC


PROGRAMMES

Lettre de l'IRIB - avril 2022

La Lettre de l’IRIB du mois d'avril 2022 (n°85) est en ligne.

Pour consulter les archives, merci de cliquer ici.

LATEST NEWS    ARCHIVE



Events


Connexion


Newsletter


CONTACT US
logo
IRIB Normandy Rouen
22 Boulevard Gambetta
76183 ROUEN Cedex
France

Direction
contact@irib-normandy.fr

Secretariat
secretariat@irib-normandy.fr

logo logo
Design by Alexis Lebon © IRIB Normandy Rouen, 2012 - All rights reserved.