Research Laboratories

Research Team EA 3830



Ventilary Handicap Research Group

GRHV


Head


Director: Pr. Jean-Paul Marie
Assistant director: Pr. Antoine Cuvelier and Dr. Nicolas Guérout
Contact person: Célia Duclos


Contact


EA 3830 GRHV
UFR Santé 22 Boulevard Gambetta
76183 Rouen Cedex
Phone: +33 2 32 14 83 88
jean-paul.marie@chu-rouen.fr
celia.duclos@univ-rouen.fr


Research Topics


  • Laryngeal reinnervation (experimental and clinical aspects)
  • Physiopathology and treatment of dysphagia and aspiration (airway protection)
  • Axonal regeneration in the peripheral nervous system
  • Acute respiratoryinsufficiency and ventilation
  • Axonal regeneration in the injured spinal cord
  • Patient and machine interactions during non invasive mechanical ventilation
  • swallowing disorders, connected to upper respiratory tract dysfunction

Composition


  • 4 professors MD-PhD, 1 associate professor PhD, 8 clinicians and 1 research technician
  • 5 PhD students
  • 4 master students

Facilities


  • ExperimentalSurgeryLaboratory
  • TechnologicalResearchLaboratory
  • Bench for ventilatory devices testing (lung test Ingmar)
  • PhysiologyLaboratory
  • Clinical Departments in the University Hospital (Pneumology, Intensive Care Unit, Physiology, Head & Neck Surgery, Pediatry)

Activity


The main concern of our Research Group EA 3830, GRHV (VentilatoryHandicap Research Group) is the comprehensive approach of the ventilatory handicap, and its treatment. Our research team works on 4 main subjects: 1) rehabilitation of the neuromuscular dysfunctions of the aerodigestive tract, 2) rehabilitation of diaphragm dysfunctions, 3) treatment of chronic and acute respiratory failure bymechanical ventilation and 4) treatment for spinal cord injury.
Our research group is composed of 4 professors MD-PhD, 1 associate professor PhD, 8 clinicians and 1 research technician.
Our team is involved in the Head and Neck Regenerative Surgery Federation (morphology and function) - Fédération-Hospitalo-Universitaire FHU SURFACE.


Main Contributions


Functional laryngeal re-innervation in animals and humans. Ongoing human trial on secondary re-innervation (Governmental research grant: PHRC) and grants (PHRC) obtained for laryngeal transplantation with functional re-innervation.
Relations between ventilation and swallowing.
Diaphragm re-innervation with laryngeal nerve in tetraplegic patients (PHRC).
New high flow oxygenation techniques in acute respiratory distress (NEJM publication) and non invasive ventilation modalities in chronic respiratory insufficiency.
New method of echographic measurement (strain) in right cardiac insufficiency.
Automatic physiologic measurements during sleep.
Interest of cells therapy (with olfactory ensheathing cells) in axonal regeneration, applied to neural structures implicated in ventilation.


Main Publications


2019

  • Obongo R, Bon-Mardion N, Duclos C, Strunski V, Guerout N and Marie JP. Dual innervation may occur in a partially denervated muscle. Muscle Nerve 2019, 59: 108-115.
    30121966
  • Patout M, Arbane G, Cuvelier A, Muir JF, Hart N and Murphy PB. Polysomnography versus limited respiratory monitoring and nurse-led titration to optimise non-invasive ventilation set-up: a pilot randomised clinical trial. Thorax 2019, 74: 83-86.
    29602814

2018

  • Medrinal C, Combret Y, Prieur G, Robledo Quesada A, Bonnevie T, Gravier FE, Dupuis Lozeron E, Frenoy E, Contal O and Lamia B. Comparison of exercise intensity during four early rehabilitation techniques in sedated and ventilated patients in ICU: a randomised cross-over trial. Crit Care 2018, 22: 110.
    29703223
  • Ouahchi Y, Ben Salah N, Mjid M, Hedhli A, Abdelhedi N, Beji M, Toujani S and Verin E. Breathing pattern during sequential swallowing in healthy adult humans. J Appl Physiol (1985) 2018
    30412029

2017

  • Béduneau G, Pham T, Schortgen F, Piquilloud L, Zogheib E, Jonas M, Grelon F, Runge I, Nicolas Terzi, Grangé S, Barberet G, Guitard PG, Frat JP, Constan A, Chretien JM, Mancebo J, Mercat A, Richard JM and Brochard L; WIND (Weaning according to a New Definition) Study Group and the REVA (Réseau Européen de Recherche en Ventilation Artificielle) Network. Epidemiology of Weaning Outcome according to a New Definition. The WIND Study. Am J Respir Crit Care Med 2017, 195: 772-783.
    27626706
  • Lamia B, Muir JF, Molano LC, Viacroze C, Benichou J, Bonnet P, Quieffin J, Cuvelier A and Naeije R. Altered synchrony of right ventricular contraction in borderline pulmonary hypertension. Int J Cardiovasc Imaging 2017, 33: 1331-1339.
    28317064

2016

  • Frat JP, Ragot S, Girault C, Perbet S, Prat G, Boulain T, Demoule A, Ricard JD, Coudroy R, Robert R, Mercat A, Brochard L and Thille AW; REVA network. Effect of non-invasive oxygenation strategies in immunocompromised patients with severe acute respiratory failure: a post-hoc analysis of a randomised trial. Lancet Respir Med 2016, 4: 646-652.
    27245914
  • Li X, Floriddia EM, Toskas K, Fernandes KJL, Guérout N and Barnabé-Heider F. Regenerative Potential of Ependymal Cells for Spinal Cord Injuries Over Time. EBioMedicine 2016, 13: 55-65.
    27818039