Inserm Unit U1239 |
Neuroendocrine, Endocrine and Germinal Differentiation Communication
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NORDIC
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HeadHervé LEFEBVRE Jérôme LEPRINCE |
ContactInserm U1239 Faculty of Sciences University of Rouen 76821 Mont-Saint-Aignan Phone: +33 235 14 6743/6731/6661 secretariat-u1239.inserm@univ-rouen.fr |
http://dc2n.labos.univ-rouen.fr/
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Research Topics
- Functional genomics of a novel neuroendocrine thioredoxin - Genomics and pathophysiology of neurosecretion - Identification of markers and therapeutic strategies for neuroendocrine and non-neuroendocrine tumors
- Determination of therapeutic potential of the neuropeptides PACAP and ODN in models of cerebral ischemia - Determination of therapeutic potential of stem cells expressing PACAP for the treatment of cerebral ischemia - Development of tools to study brain development and aging
- Chemotactic GPCRs on molecular signallings and cellular mechanisms in development of gliomas including angiogenesis, invasion, tumoral heterogenity and treatment resistance - Impact of cancer and cancer therapies on brain function and new prevention strategies (Cancer and cognition platform) - Development of local strategies for glioma treatment and functional rehabilitation in preclinical models
- Identification of novel molecular targets for the therapeutic management of hypercorticisms - Characterization of novel neuropeptides involved in the central and peripheral control of energy metabolism |
Composition
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Facilities
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ActivityThe central theme of the four research groups of the INSERM U1239 within IRIB is devoted to neuronal and neuroendocrine differentiation and communication. Several pathologies of the central nervous system (neurodegenerative diseases, lissencephaly, brain tumors) and the neuro-endocrine system (obesity, diabetes, neuroendocrine tumors) are associated to abnormalities in cell differentiation, migration, survival and intercommunication. The research project of our Unit aims to contribute to the elucidation of the cellular and molecular mechanisms of neuronal and neuroendocrine differentiation and communication involving neuropeptides, in physiology and pathophysiology. Peptides such as PACAP, urotensin II and ACTH are implicated in cell growth and differentiation or neurotransmitter/hormone release, during development and in adulthood. Studies are conducted to determine the role of trophic peptides, and certain genes involved in their effects (selenoprotein T, chromogranins, G protein-coupled receptors) as revealed by transcriptomic and proteomic analyses, in processes of cell differentiation, neuroprotection, hormone regulation and tumorigenesis. Using a multidisciplinary approach of neuroscience and neuroendocrinology based on cell imaging, electrophysiology, neurotransmitter/ hormone release assays, gene disruption, peptide characterization, etc, in vivo and in vitro, our research groups contribute to the understanding of basic mechanisms underlying neuronal and neuroendocrine function of neuropeptides. Pre-clinical and clinical investigations allow us to determine the pathophysiological implications of peptide-associated effects in animal models and human, respectively. Thus, beside the cognitive aspects of our research project, the ultimate goal is to identify, develop and validate therapeutic strategies (e.g. Urotensin II, PACAP analogs and signaling targets) as well as diagnostic/prognostic tools (e.g. EM66 biomarker), in collaboration with Rouen CHU services, CIC and IRIB laboratories, national networks (COMETE, PGL-EVA, REHOS, Cog-Immuno, Canceropole, ANOCEF, GDR-GPCR, Onconeurotox, OncoThera), partners in the pharmaceutical industry and numerous international research groups (LARC Neurosciences Network, ens@t, ICCTF, the COST Network ERNEST). |
Main Contributions
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Main Publications2018
2017
2016
2015 |