Research Unit UMR7510 |
Foodborne protozoan diseases
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ESCAPE
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HeadIsabelle Villena / Loïc Favennec |
ContactParasitology Team Faculté de Médecine et de Pharmacie 22 Boulevard Gambetta 76183 Rouen Cedex Phone: +33 235 14 8581 loic.favennec@univ-rouen.fr |
Research Topics
Waterborne and foodborne protozoa: Toxoplasma; Cryptosporidium, Giardia, Acanthamoeba
Molecular epidemiology of cryptosporidiosis and giardiasis
Development of new methods for protozoa detection in complex matrices
Anti-protozoal treatments
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Composition
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Facilities
In vitro cultivation of protozoa (Cryptosporidium, Giardia and Acanthamoeba)
In vivo model of infection : Acanthamoeba, Cryptosdporidium, Giardia
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ActivityWorks of EA 3800 research unit are aimed to study epidemiology of cryptosporidiosis, pathogenicity and treatment of Cryptosporidium and other waterborne protozoa (Giardia and Acanthamoeba). For this, in the laboratory have been developed various in vitro and animal models. In association with the French network for cryptosporidiosis "Crypto Anofel", coordinated by L. Favennec, in a "One health" perspective, EA3800 investigates the molecular epidemiology of animal and human cryptosporidiosis, evaluating different epidemiological and pathological genetic markers. Moreover, we study cellular and molecular pathways involved in diarrhea triggered by Cryptosporidium. In the field of innovative antiprotozoal therapy, we investigate the activity and mechanisms of action of new thiazolides on Cryptosporidium - host cell interactions and the activity of PHMB and azoles on the treatment of Acanthamoeba keratitis. |
Main ContributionsDevelopment of Cryptosporidium hominis animal model Development of polyhexamethylene biguanide for Acanthamoeba keratitis therapy Development of thiazolides for cryptosporidiosis therapy Development of Cryptosporidium hominis animal model Development of polyhexamethylene biguanide for Acanthamoeba keratitis therapy
Development of thiazolides for cryptosporidiosis therapy
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Main Publications2016
2015
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