IRIB Normandy Rouen / Institute for Research and Innovation in Biomedicine

  Research and Services Laboratories

UR7510 - ESCAPE - EpidémioSurveillance et Circulation des Parasites dans les Environnements


 https://hal-normandie-univ.archives-ouvertes.fr/ESCAPE-ROUEN

Head: Loïc FAVENNEC

  Contact

Parasitology Team
Faculté de Médecine et de Pharmacie
22 Boulevard Gambetta
76183 Rouen Cedex
Phone: +33 235 14 8581
 loic.favennec@univ-rouen.fr


  Keywords
PROTOZOA IN HUMAN HEALTH, PROTOZOA (Toxoplasma, Cryptosporidium and Giardia), PATHOGENESIS, DRUG RESISTANCE, VIRULENCE, FOOD AND ENVIRONMENTAL PROTOZOOSES, CIRCULATION OF INFECTIOUS AGENTS, ONE HEALTH, EPIDEMIOSURVEILLANCE, ZOONOSES

  Composition

  Facilities

In vitro cultivation of protozoa (Cryptosporidium, Giardia and Acanthamoeba)

In vivo model of infection  : Acanthamoeba, Cryptosdporidium, Giardia


  Activity

Works of EA 3800 research unit are aimed to study epidemiology of cryptosporidiosis, pathogenicity and treatment of Cryptosporidium and other waterborne protozoa (Giardia and Acanthamoeba). For this, in the laboratory have been developed various in vitro and animal models. In association with the French network for cryptosporidiosis "Crypto Anofel", coordinated by L. Favennec, in a "One health" perspective, EA3800 investigates the molecular epidemiology of animal and human cryptosporidiosis, evaluating different epidemiological and pathological genetic markers. Moreover, we study cellular and molecular pathways involved in diarrhea triggered by Cryptosporidium. In the field of innovative antiprotozoal therapy, we investigate the activity and mechanisms of action of new thiazolides on Cryptosporidium - host cell interactions and the activity of PHMB and azoles on the treatment of Acanthamoeba keratitis.


  Main contributions

Development of Cryptosporidium hominis animal model

Development of polyhexamethylene biguanide for Acanthamoeba keratitis therapy

Development of thiazolides for cryptosporidiosis therapy

Development of Cryptosporidium hominis animal model

Development of polyhexamethylene biguanide for Acanthamoeba keratitis therapy

Development of thiazolides for cryptosporidiosis therapy


  Latest publications

2016

2015


Last update: 2020/02/13

Nous contacter :

IRIB Normandy Rouen
22 Boulevard Gambetta
76183 ROUEN Cedex
France

Direction :
contact@irib-normandy.fr

Secretariat :
secretariat@irib-normandy.fr

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