Parasitology Team
Faculté de Médecine et de Pharmacie
22 Boulevard Gambetta
76183 Rouen Cedex
Phone: +33 235 14 8581 loic.favennec@univ-rouen.fr
In vitro cultivation of protozoa (Cryptosporidium, Giardia and Acanthamoeba)
In vivo model of infection : Acanthamoeba, Cryptosdporidium, Giardia
Works of EA 3800 research unit are aimed to study epidemiology of cryptosporidiosis, pathogenicity and treatment of Cryptosporidium and other waterborne protozoa (Giardia and Acanthamoeba). For this, in the laboratory have been developed various in vitro and animal models. In association with the French network for cryptosporidiosis "Crypto Anofel", coordinated by L. Favennec, in a "One health" perspective, EA3800 investigates the molecular epidemiology of animal and human cryptosporidiosis, evaluating different epidemiological and pathological genetic markers. Moreover, we study cellular and molecular pathways involved in diarrhea triggered by Cryptosporidium. In the field of innovative antiprotozoal therapy, we investigate the activity and mechanisms of action of new thiazolides on Cryptosporidium - host cell interactions and the activity of PHMB and azoles on the treatment of Acanthamoeba keratitis.
Development of Cryptosporidium hominis animal model
Development of polyhexamethylene biguanide for Acanthamoeba keratitis therapy
Development of thiazolides for cryptosporidiosis therapy
Development of Cryptosporidium hominis animal model
Development of polyhexamethylene biguanide for Acanthamoeba keratitis therapy
Development of thiazolides for cryptosporidiosis therapy